Antidepressants – SNRIs, SSRIs, TCAs, MAOIs and NASSAs



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Serotonin and noradrenaline reuptake inhibitors (SNRIs) are used to treat major depression, mood disorders, and possibly but less commonly attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety disorders, menopausal symptoms, fibromyalgia, and chronic neuropathic pain.

SNRIs raise levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a key role in stabilizing mood.

Examples include duloxetine (Cymbalta), venlafaxine (Effexor) and desvenlafaxine (Pristiq).



Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are effective in treating depression, and they have fewer side effects than the other antidepressants.

SSRIs block the reuptake, or absorption, of serotonin in the brain. This makes it easier for the brain cells to receive and send messages, resulting in better and more stable moods.

They are called “selective” because they mainly seem to affect serotonin, and not the other neurotransmitters.

Examples include citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil) and sertraline (Zoloft).


Tricyclic antidepressants (TCAs)

Tricyclic antidepressants (TCAs) are so named because there are three rings in the chemical structure of these medications. They are used to treat depression, fibromyalgia, some types of anxiety, and they can help control chronic pain.

Examples include amitriptyline (Elavil), amoxapine- clomipramine (Anafranil)



Monoamine oxidase inhibitors (MAOIs)

This type of antidepressant was commonly prescribed before the introduction of SSRIs and SNRIs.

It inhibits the action of monoamine oxidase, a brain enzyme. Monoamine oxidase helps break down neurotransmitters, such as serotonin.

If less serotonin is broken down, there will be more circulating serotonin. In theory, this leads to more stabilized moods and less anxiety.

Doctors now use MAOIs if SSRIs have not worked. MAOIs are generally saved for cases where other antidepressants have not worked because MAOIs interact with several other medications and some foods.


Examples of MAOIs include phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan) and selegiline (EMSAM, Eldepryl).



Noradrenaline and specific serotoninergic antidepressants (NASSAs)

These are used to treat anxiety disorders, some personality disorders, and depression.

Examples include Mianserin (Tolvon) and Mirtazapine (Remeron, Avanza, Zispin).




WELLBUTRIN is used to treat depressive disorders. WELLBUTRIN is thought to interact with substances in the brain called norepinephrine and dopamine, which have been linked to depression.


Unless otherwise prescribed by your doctor, the starting dose of the medicine is:

150 mg / 1 tablet / once daily.
If there is no improvement after a few weeks of treatment, your doctor may prescribe a higher dose – 2 tablets a day.
Take your dose of WELLBUTRIN in the morning.
Do not take more than 1 tablet at a time. The interval between doses should be at least 8 hours.




Duloxetine 60 mg * 30 | Venlafaxine XR 75 mg prolonged release capsules * 30 by MEDOCHEMIE | Anafranil (clomipramine) 25 mg * 30 by NOVARTIS | Fluvoxamine maleate 100 mg * 30 MYLAN | Amitriptyline 25 mg * 30 by MYLAN | Mirtazapine 30 mg * 30 by ACTAVIS | Selegiline hydrochloride 5 mg * 30 MEDOCHEMIE | Citalopram 20 mg * 30 ACTAVIS | Prozac Fluoxetine 20 mg * 24 Lilly | Escitalopram 10 mg * 28 | Venlafaxine 75 mg prolonged release capsules * 30 MEDOCHEMIE | Trazodone 150 mg prolonged release tablets * 20 AngeliniPharma | Agomelatine 25 mg * 30 GEROT | Vortioxetine  Fonksera  5 mg * 28 LUNDBECK | EDRONAX (reboxetine) 4 mg * 60 PFIZER | Tianeptine 12.5 mg * 30 SERVIER | Flupentixol/melitracen 0.5/10 mg * 100 LUNDBECK | Wellbutrin (bupropion) XR 150 mg * 30 GlaxoSmithKline


Amitriptyline has an average rating of 7.5 out of 10 from a total of 1,702 reviews on 68% of reviewers reported a positive experience, while 17% reported a negative experience.


Duloxetine has an average rating of 6.1 out of 10 from a total of 2,359 reviews on 52% of reviewers reported a positive experience, while 32% reported a negative experience.


Venlafaxine has an average rating of 6.4 out of 10 from a total of 2,687 reviews on 53% of reviewers reported a positive experience, while 29% reported a negative experience.



Fluvoxamine has an average rating of 6.7 out of 10 from a total of 358 reviews on 56% of reviewers reported a positive experience, while 25% reported a negative experience.



Mirtazapine has an average rating of 6.7 out of 10 from a total of 1,926 reviews on 55% of reviewers reported a positive experience, while 22% reported a negative experience.



Selegiline has an average rating of 7.9 out of 10 from a total of 63 reviews on 76% of reviewers reported a positive experience, while 12% reported a negative experience.


Citalopram has an average rating of 7.4 out of 10 from a total of 2,176 reviews on 67% of reviewers reported a positive experience, while 15% reported a negative experience.

Condition Avg. Rating Reviews Compare
Anxiety and Stress
976 reviewsfor Anxiety and Stress 9 medications
722 reviewsfor Depression 77 medications
Generalized Anxiety Disorder  Off-label
210 reviewsfor Generalized Anxiety Disorder 7 medications
Panic Disorder  Off-label
110 reviewsfor Panic Disorder 18 medications
Obsessive Compulsive Disorder  Off-label
44 reviewsfor Obsessive Compulsive Disorder 9 medications
Postpartum Depression
29 reviewsfor Postpartum Depression 8 medications



Fluoxetine has an average rating of 7.3 out of 10 from a total of 2,116 reviews on 65% of reviewers reported a positive experience, while 19% reported a negative experience.


Escitalopram has an average rating of 7.4 out of 10 from a total of 3,715 reviews on 67% of reviewers reported a positive experience, while 16% reported a negative experience.